SOME EFFECTS OF SIMULTANEOUS ADMINISTRATION OF CRUDE AQUEOUS EXTRACTS OF MANGIFERA INDICA LEAVES AND TETRACYLINE ON THE LIVER OF ADULTS WISTAR RATS.

Peterson M.S. Atiba, Adesina J. Ajibade, Peter B. Olaitan
Correspondence to Peterson M.S. Atiba, Department of Anatomy, College of Medicine, University Of Ibadan, Ibadan, Oyo State. Nigeria. P.O BOX 56, OSOGBO, OSUN STATE, NIGERIA. petersonatiba@yahoo.com. +2348030947446

ABSTRACT
This study was designed to determine the simultaneous effect of Mangifera indica crude aqueous extract and the therapeutic dose of tetracycline on some hepatic enzymes (ALT and AST) and histology of the liver of adult wistar rats. 25 wistar rats were divided into 5 groups: Group A was untreated and served as control group, group B was treated with only 2mL of mango leaves decoction, group C was treated with only 5.4mg/kg of tetracycline, group D was treated with 1mL of mango leaves decoction and 4.8mg/kg of tetracycline and group E was treated with 3mL of mango leaves decoction and 7.7mg/kg of tetracycline simultaneously. The administration period lasted for only 14 days which was given gavagely and the rats were sacrificed on the 15th day by cervical dislocation. The liver was removed, fixed in 10% formal saline and stained in H and E. The transaminase enzymes (the AST and ALT) were measured to determine possible changes in their hepatic leaves. The result shows that the crude aqueous extract of mango levels has adverse effect on the morphology and some hepatic enzyme (ALT and AST) of the liver (such as enlargement of the central vein, reduction in the size of sinusoids), the therapeutic dose of the tetracycline have no detrimental effect on the morphology and the hepatic enzymes of the liver. In conclusion, the extract of mango leaves decoction has adverse effect on the liver histology and the therapeutic dosage of tetracycline has no adverse effect on the histology of the liver.
Keywords: Mango leaves, Tetracycline, Liver histology, Liver enzymes (AST and ALT)
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